The HSD11B1 antibody from MyBioSource.com is a Rabbit Polyclonal antibody to 11beta-HSD1, HSD11B, and HSD11B1. This antibody recognizes Human antigen. The HSD11B1 antibody has been validated for the following applications: Western Blot.
Description
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein